Peptide substrates, method of preparation and use in the determination of protein C
US5362851A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 2, 1991 |
| Grant date | Nov 8, 1994 |
| Priority date | — |
| Expiry date | Oct 2, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates, by way of novel industrial products, to peptide compounds selected from the group consisting of PA1 (i) the tripeptides of the formula EQU Y--A.sub.1 --A.sub.2 --A.sub.3 --R (I) PA1 in which PA1 Y is H or an appropriate group blocking the N-terminal end, PA1 A.sub.1 is an amino acid residue selected from the group consisting of (2-oxothiazolidin-4-yl)carbonyl [abbreviated to THC], (2-oxotetrahydro-1,3-thiazin-5yl)carbonyl [abbreviated to TZC], thiazolidine-4-carbonyl [abbreviated to ATC] and (tetrahydro-1,3-thiazin-5-yl)carbonyl [abbreviated to AZC] residues, PA1 A.sub.2 is an amino acid residue selected from the group consisting of Pro, 3Hyp and 4Hyp residues, where the OH side-group of 3Hyp and 4Hyp is capable of being protected by an ether or ester protecting group, PA1 A.sub.3 is an amino acid residue selected from the group consisting of Arg and Lys residues, and PA1 R is a labeling means; and PA1 (ii) their addition salts. PA1 These novel compounds are useful as substrates in the determination of Protein C.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.