Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties
US5362852A · kind A · utility
154Cited by
2References
11Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Sep 27, 1991 |
| Grant date | Nov 8, 1994 |
| Priority date | — |
| Expiry date | Sep 27, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2121/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process is disclosed for site-directed chemical modification of peptides and proteins that consists of two steps; (a) selective oxidation of a 2-hydroxyethylamine moiety, --CH(NH.sub.2)--CH(OH)--, in the peptide or protein to generate an aidehyde, and (b) reaction of the new aldehyde with a second reagent to form a product in which the native biological properties of the peptide are augmented by new and useful properties conferred by the second reagent. Additionally, the invention pertains to certain specified types of product formed by the above process.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.