Patent · US Expired

Polychelants containing macrocyclic chelant moieties

US5364613A · kind A · utility

90Cited by

11References

33Claims

0Family size

Inventors

Paul F. Sieving · San Jose, US
Alan D. Watson · Wayne, US
Steven C. Quay · Edmonds, US
Scott M. Rocklage · Saratoga, US

Key dates

Filing date	Jan 16, 1990
Grant date	Nov 15, 1994
Priority date	—
Expiry date	Jan 16, 2010

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC08G69/48
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

There are provided polychelants and their metal chelates which are useful in diagnostic imaging and in radiotherapy and which comprise a plurality of macrocyclic chelant moieties, e.g, DOTA residues, conjugated to a polyamine backbone molecule, e.g, polylysine. To produce a site-specific polychelate, one or more of the macrocyclic chelant carrying backbone molecules may be conjugated to a site-directed macromolecule, e.g. a protein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.