Amino-substituted benzoylguanidines, process for their preparation, their use as a medicament and medicament containing them

US5364868A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Heinrich Englert · Hofheim, DE
• Dieter Mania · Königstein, DE
• Hans-Jochen Lang · Hofheim, DE
• Wolfgang Scholz · Beverly, US
• Wolfgang Linz · Mainz, DE
• Udo Albus · Florstadt, DE

Key dates

• Filing date: Feb 11, 1993
• Grant date: Nov 15, 1994
• Expiry date: Feb 11, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/65
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Amino-substituted benzoylguanidines, process for their preparation, their use as a medicament and medicament containing them Benzoylguanidines of the formula I ##STR1## are described in which R(1) or R(2) is an amino group --NR(3)R(4), where R(3) and R(4) are H or (cyclo)alkyl or R(3) is phenyl-(CH.sub.2).sub.p -- where p=0, 1, 2, 3 or 4, or phenyl, or R(3) and R(4) can also together be a methylene chain, and in which the other substituent R(1) or R(2) in each case is H, F, Cl, alkyl, alkoxy, CF.sub.3, C.sub.m F.sub.2m+1 --CH.sub.2 --, benzyl or phenoxy, and their pharmaceutically tolerable salts. The compounds according to the invention have very good antiarrhythmic properties, as occur, for example, in the case of oxygen deficiency symptoms. The compounds are used as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment as well as for the treatment of angina pectoris, where they also preventively inhibit or greatly decrease the pathophysiological processes in the formation of ischemically induced damage, in particular in the production of ischemically induced cardiac arrhythmias.