Indole derivatives as 5-lipoxygenase inhibitors
US5364877A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Oct 8, 1993 |
| Grant date | Nov 15, 1994 |
| Priority date | — |
| Expiry date | Oct 8, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention concerns a bicyclic heterocyclic derivative of the formula I ##STR1## wherein Q is an optionally substituted 9-membered bicyclic heterocyclic moiety containing 1 or 2 N's and optionally a further N, O or S heteroatom; PA1 A.sup.1 is a direct link to X.sup.1 or (1-3C)alkylene; PA1 X.sup.1 is oxy, thio, sulphinyl, sulphonyl or imino; PA1 Ar is optionally substituted phenylene or pyridylene; PA1 R.sup.1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; and PA1 R.sup.2 and R.sup.3 together form a group of the formula --A.sup.2 --X.sup.2 --A.sup.3 -- which, together with the carbon atom to which A.sup.2 and A.sup.3 are attached, defines a ring having 5 to 7 ring atoms, wherein each of A.sup.2 and A.sup.3 is (1-3C)alkylene and X.sup.2 is oxy, thio, sulphinyl or sulphonyl; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.