Non-glycosylated variants of extracellular superoxide dismutase (EC-SOD)
US5366729A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 13, 1992 |
| Grant date | Nov 22, 1994 |
| Priority date | — |
| Expiry date | May 13, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/40
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Extracellular superoxide dismutase (EC-SOD) variants having the superoxide dismutating property of the native EC-SOD and having a modified (reduced or increased) binding to heparin as compared to recombinant EC-SOD C as well as compositions comprising such variants. The EC-SOD variants are polypeptides comprising: 1) amino acids 1-193 of native EC-SOD C and 2) an amino acid sequence which is based on, but different from amino acid moieties 194-222 of recombinant EC-SOD C, either by being truncated or prolonged at the C-terminal end or by having substituted or otherwise modified one or more amino acid moieties of the sequence. Another EC-SOD variant is one which differs from recombinant EC-SOD C by being a glycosylation-free mutant. The variants may be produced by recombinant DNA techniques and are useful in the treatment of various diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.