Stabilized compositions having human tissue type plasminogen activator enzymatic activity

US5366730A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Ulrich Kohnert · Habach, DE
• Rainer Rudolph · Waldshut-Tiengen, DE

Key dates

• Filing date: Apr 6, 1993
• Grant date: Nov 22, 1994
• Expiry date: Apr 6, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmaceutical preparation of a protein with t-PA activity with an enzymatic activity of at least 0.25 MU/ml. and a pH value of 4.5 to 9 which contains a substance of the group citric acid, ascorbic acid, 2-oxoglutaric acid, fumaric acid, Tris and EDTA in a concentration of at least 0.2 mole/l., as well as a medicament based on a protein with t-PA activity and processes for its preparation.