Compounds which inhibit complement and/or suppress immune activity
US5366986A · kind A · utility
5Cited by
17References
30Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Dec 6, 1990 |
| Grant date | Nov 22, 1994 |
| Priority date | — |
| Expiry date | Dec 6, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to compounds which suppress immune responses and/or selectively inhibit complement. These compounds contain an aromatic ring and are substituted dihydrobenzofurans, spirobenzofuran-2(3H)-cycloalkanes, and their open chain intermediates. The compounds of the present invention, and the phamaceutically acceptable salts thereof, interrupt the proteolytic processing of C5 to bioactive components, exhibit immunosuppressive activites, and have therapeutic utility in the amelioration of disease and disorders mediated by complement and/or immune activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.