Modified antibodies with increased affinity
US5367058A · kind A · utility
15Cited by
1References
6Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Aug 25, 1993 |
| Grant date | Nov 22, 1994 |
| Priority date | — |
| Expiry date | Aug 25, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K49/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to modified antibodies and fragments which display an increased affinity for antigen as compared to the affinity of unmodified antibody for antigen. The most preferred modification is the addition of a thiol group on the surface of the antibody such that a covalent bond forms between the antibody and antigen when they bind to one another.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.