Convenient process for the preparation of chiral or racemic phenylalaninols and their N-blocked derivatives
US5367094A · kind A · utility
1Cited by
2References
12Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 4, 1993 |
| Grant date | Nov 22, 1994 |
| Priority date | — |
| Expiry date | Jun 4, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C213/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention pertains to an improved process for preparing chiral or racemic phenylalaninol (PAO) by hydrogenation of L(+)- or racemic 2-amino-1-phenyl-1,3-propanediol (APPD) in the presence of a strong volatile acid. Furthermore, a more valuable form of PAO such like N-blocked PAO was found to be directly produceable from the hydrogenation mixture without isolation of PAO, when a volatile acid was used as the medium of the hydrogenation reaction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.