Modulator agent and use thereof
US5369111A · kind A · utility
5Cited by
1References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 19, 1992 |
| Grant date | Nov 29, 1994 |
| Priority date | — |
| Expiry date | Jun 19, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/475
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Sensitizing tumoral cells to anticancerous drugs and/or inhibiting the tumoral cells resistance to antitumoral drugs employing as a modulator agent a vinca alkaloid dimer, analog to vinblastine or vincristine, with a low cytotoxicity or devoid of cytotoxicity, comprising at least one stereoisomerism different from that of vinblastine or vincristine in the C-14', C-16' or C-20' position. Notably, the modulator agent may have the R absolute configuration in the C-16' position.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.