Cholesterol-lowering agents
US5369125A · kind A · utility
18Cited by
7References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 19, 1993 |
| Grant date | Nov 29, 1994 |
| Priority date | — |
| Expiry date | Mar 19, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents and antifungal agents. These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.