Pharmaceutical hydrophilic spray containing nitroglycerin for treating angina

US5370862A · kind A · utility

Assignee

• Schwarz Pharma Ltd. · DE

Inventors

• Karin Klokkers-Bethke · Monheim, DE
• Ulrich Munch

Key dates

• Filing date: Dec 11, 1992
• Grant date: Dec 6, 1994
• Expiry date: Dec 11, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/21
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A pharmaceutical aerosol spray for treating an angina attack including a container having a liquid composition therein comprising 0.1 to 2 weight percent of nitroglycerin, 2 to 60 weight percent of ethanol, 2 to 60 weight percent of propylene glycol, 10 to 50 weight percent of dichlorodifluoromethane and 30 to 70 weight percent of dichlorotetrafluoroethane, the container having a valve assembly sealed to the container around an opening in the container by a sealant material which has a nitroglycerin absorption value less than 10 mg/1 g of sealant material.