Asp-Pro-Arg .alpha.-keto-amide enzyme inhibitors
US5371072A · kind A · utility
43Cited by
5References
35Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 16, 1992 |
| Grant date | Dec 6, 1994 |
| Priority date | — |
| Expiry date | Oct 16, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Asp-Pro-Arg alpha-keto-amide derivatives, and their pharmaceutically acceptable salts and compositions, for use as antithrombotic agents in mammals are disclosed. The method of use of these inhibitor compounds for treatment or prevention of conditions of abnormal thrombus formation in mammals is also disclosed. Further disclosed are alpha-hydroxy amide compounds used as intermediates in the preparation of the keto-amide compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.