Process for the stereoselective preparation of .beta.-fucopyranosyl phosphates and very pure GDP-fucose

US5371203A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Richard Schmidt · Konstanz, DE
• Karl-Heinz Jung · Konstanz, DE
• Barbara Spahngehl · Munich, DE
• Willy Kinzy · Inzlingen, DE
• Jurgen Hemberger · Aschaffenburg, DE

Key dates

• Filing date: Jan 31, 1992
• Grant date: Dec 6, 1994
• Expiry date: Jan 31, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a process for the stereoselective preparation of .beta.-L-fucopyranosyl phosphates via the trichloroacetimidates of protected L-fucose and the synthesis and purification of very pure GDP-fucose from the .beta.-L-fucopyranosyl phosphates.