Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5371210A · kind A · utility
44Cited by
7References
27Claims
0Family size
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Key dates
| Filing date | Jun 22, 1992 |
| Grant date | Dec 6, 1994 |
| Priority date | — |
| Expiry date | Jun 22, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A stereoselective fusion glycosylation process for preparing beta-anomer enriched 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides is provided which requires reacting an alpha-anomer enriched 2-deoxy-2,2-difluorocarbohydrate or 2-deoxy-2-fluorocarbohydrate with at least 3 molar equivalents of a nucleobase derivative at a temperature sufficient to fuse the carbohydrate and nucleobase; in the absence of a catalyst and a solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.