Process for the production of 4-hydroxy-2-oxopyrrolidin-1-yl-acetamide
US5371237A · kind A · utility
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Key dates
| Filing date | Jan 29, 1993 |
| Grant date | Dec 6, 1994 |
| Priority date | — |
| Expiry date | Jan 29, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/38
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Process for the production of 4-hydroxy-2-oxoyrrolidin-1-yl-acetamide, a cerebrally active pharmaceutical agent. A 4-halo-3-alkoxy-butenoic acid ester is reacted with glycine to new intermediate products of the formula: ##STR1## There is further by acid hydrolysis of the alkoxy group, subsequent hydrogenation, esterification of the carboxyl function and finally conversion to the end product by reaction with ammonia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.