Synthesis of ioversol using a minimal excess of acetoxyacetylchloride

US5371278A · kind A · utility

Assignee

• Mallinckrodt Medical PMC · US

Inventors

• William Z. McCarthy · Chesterfield, US
• Mills T. Kneller · University City, US
• Youlin Lin · Chesterfield, US
• Rebecca A. Wallace · Manchester, US
• David H. White · Ballwin, US

Key dates

• Filing date: Mar 25, 1994
• Grant date: Dec 6, 1994
• Expiry date: Mar 25, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C231/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The use of a minimal excess of acetoxyacetylchloride as a reagent in the synthesis of N,N'-bis(2,3-dihydroxypropyl)-5-N-(2-hydroxy-ethyl)glycolamido-2,4,6-triio doisophthalamide.