Compositions of iodophenyl esters and iodophenyl sulfonates in film-forming materials for visualization of the gastrointestinal tract

US5372800A · kind A · utility

Assignee

• Sterling Winthrop Inc. · US

Inventors

• Edward R. Bacon · East Greenbush, US
• Sol J. Daum · Albany, US
• Kimberly G. Estep · Pottstown, US
• Kurt A. Josef · Wayne, US
• Brent Douty · Coatesville, US
• Carl R. Illig · Phoenixville, US

Key dates

• Filing date: Feb 4, 1994
• Grant date: Dec 13, 1994
• Expiry date: Feb 4, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K49/0433
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract wherein PA1 X= ##STR2## Z=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; PA1 R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, aryl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl, lower-alkenyl, lower-alkynyl, lower-alkylene or lower-alkoxy-carbonyloxy, PA1 n is 1-5; PA1 y is 0-4; and PA1 w is 1-4.