Polymers containing antifibrotic agents, compositions containing such polymers, and methods of preparation and use

US5372807A · kind A · utility

Assignees

• University of Medicine and Dentistry of New Jersey · US
• Rutgers University · US

Inventors

• George J. Poiani · Jamesburg, US
• David J. Riley · New Brunswick, US
• Wei-Chi Liao · Douliu, TW
• Joachim Kahn · Ehringshausen, DE
• Keria Fiorella Gean · Highland Park, US

Key dates

• Filing date: Aug 24, 1992
• Grant date: Dec 13, 1994
• Expiry date: Aug 24, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G81/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention concerns a method for treating fibrotic conditions by administration of an effective amount of an antifibrotic agent. The antifibrotic agent is preferably a proline analog, such as cis-4-hydroxy-L-proline (cHyp). The antifibrotic agent is operatively linked to a monomer or a polymer, with or without a linking compound, e.g., lysine. Intravenous administration is preferred. The present method facilitates the delivery and release of the antifibrotic agent to inhibit collagen accumulation and thereby to treat fibrosis where collegen metabolism is implicated. A reduced quantity of the antifibrotic agent and a corresponding reduction in the potential for toxicity resulting from prolonged administration thereof may be realized.