Method of treatment of androgen-related diseases
US5372996A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Oct 19, 1992 |
| Grant date | Dec 13, 1994 |
| Priority date | — |
| Expiry date | Oct 19, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J71/001
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of treatment of androgen-related diseases such as prostate cancer in susceptible male animals, including humans, comprises administering novel antiandrogens and/or novel sex steroid biosynthesis inhibitors as part of a combination therapy. Sex steroid biosynthesis inhibitors, especially those capable of inhibiting conversion of dehydroepiandrosterone (DHEA) or 4-androstenedione (.DELTA..sup.4 -dione) to natural sex steroida (and testosterone into dihydrotestosterone) in peripheral tissues, are used in combination with antiandrogens usually after blockade of testicular hormonal secretions. Antiestrogens can also be part of the combination therapy. Pharmaceutical compositions and two, three, four and five component kits are useful for such combination treatment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.