Method of using cytokine receptors on microorganism
US5374423A · kind A · utility
6Cited by
5References
3Claims
0Family size
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Key dates
| Filing date | Aug 27, 1993 |
| Grant date | Dec 20, 1994 |
| Priority date | — |
| Expiry date | Aug 27, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/922
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Cytokine receptors for tumor necrosis factor e which are found on microorganisms may, if bound with exogenous TNF.alpha., enhance the response of natural killer cells activated by the microorganisms, or increase TNF.alpha. production by peripheral blood lymphocytes treated with the microorganisms. Microorganisms with receptor-bound exogenous TNF.alpha. have enhanced cellular invasion ability which may change the immune response thereto. Clinical and pharmaceutical applications of these discoveries are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.