Enhanced indole biosynthesis
US5374543A · kind A · utility
11Cited by
0References
22Claims
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Inventor
Key dates
| Filing date | Oct 2, 1992 |
| Grant date | Dec 20, 1994 |
| Priority date | — |
| Expiry date | Oct 2, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P7/22
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
DNA molecules encoding a modified tryptophan synthase beta subunit are disclosed. When expressed in a recombinant host microorganism, these polypeptide analogs enable significant levels of intracellular indole production and accumulation. In the presence of an aromatic dioxygenase enzyme, the indole so produced can be converted to indoxyl, which upon exposure to air oxidizes to indigo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.