Indole derivatives and pharmaceutical use thereof
US5374648A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 15, 1993 |
| Grant date | Dec 20, 1994 |
| Priority date | — |
| Expiry date | Apr 15, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to compounds of formula (I). ##STR1## or a salt, or metabolically labile ester thereof wherein R represents a group selected from halogen, alkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, trifluoromethyl, trifluoromethoxy, nitro, cyano, SO.sub.2 R.sub.1 or COR.sub.1 wherein R.sub.1 represents hydroxy, methoxy, or amino; m is zero or an integer 1 or 2; PA1 A represents an ethynyl group or an optionally substituted ethenyl, or PA1 cyclopropyl group or a substituted ethenyl group; PA1 X represents --O-- or NH; PA1 R.sub.2 represents an aryl group and when X represents an oxygen atom R.sub.2 may also represent a hydrogen atom or an alkyl group; which are antagonists of excitatory amino acids, to processes for their preparation and to their use in medicine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.