Process for the preparation of high-purity deferoxamine salts
US5374771A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 27, 1993 |
| Grant date | Dec 20, 1994 |
| Priority date | — |
| Expiry date | May 27, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C239/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of high-purity deferoxamine salts from filtered fermentation liquors containing deferoxamine B as active ingredient by the adsorption of the active ingredient onto an ion exchange resin and the subsequent dissolution and purification thereof, which comprises carrying out the separation of the deferoxamine salt subsequent to the concentration of the eluate by salting out from an aqueous solution or from a mixture of water and an organic solvent and purifying it by repeated salting out and/or by methods known per se, and optionally PA0 a) preparing the methanesulfonate salt by known methods, or PA0 b) passing the aqueous solution of the deferoxamine salt trough an ion exchange resin containing methanesulfonate anions as counter ions and recovering the methanesulfonate salt from the effluent, preferably by lyophilization.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.