Method of stabilizing aerosol formulations
US5376359A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 7, 1992 |
| Grant date | Dec 27, 1994 |
| Priority date | — |
| Expiry date | Jul 7, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC09K3/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of making a stabilized aerosol drug formulation is disclosed, along with the formulations so produced and metered drug inhalers containing the same. The method comprises combining a solid particulate drug composition with a fluoropolymer in a liquid fluorocarbon aerosol propellant to form a stable suspension. Further stabilization can be achieved by cooling the suspension for a time and to a temperature sufficient to adsorb the fluoropolymer to the solid particulate drug composition in the liquid fluorocarbon aerosol propellant. Preferred propellants for carrying out the invention are 1,1,1,2-tetrafluoroethane, heptafluoropropane, and mixtures thereof, and preferred fluoropolymers for carrying out the invention are fluoropolyethers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.