Expression of interferon genes in Chinese hamster ovary cells
US5376567A · kind A · utility
43Cited by
13References
90Claims
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Key dates
| Filing date | Jan 9, 1992 |
| Grant date | Dec 27, 1994 |
| Priority date | — |
| Expiry date | Jan 9, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/811
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
DNA constructs are prepared which operably link human interferon genes, selective, eukaryotic marker genes, and promoter and expression control sequences for the expression of human interferon in Chinese hamster ovary (CHO) cells or progeny thereof. The human recombinant interferon so produced contains glycans which are a subset of the population of glycans which are contained in the native counterpart, and may be used in therapeutic formulations. The CHO cells yield high levels of human interferon with no detectable amounts of host, IFN, either constitutive or inductive.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.