Cyclodextrin based erythropoietin formulation
US5376632A · kind A · utility
19Cited by
4References
4Claims
0Family size
Inventors
Key dates
| Filing date | Jun 30, 1992 |
| Grant date | Dec 27, 1994 |
| Priority date | — |
| Expiry date | Jun 30, 2012 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB82Y5/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a new pharmaceutical composition for parenteral and local administration comprising an aqueous solution of erythropoietin and a .beta.- or .gamma.-cyclodextrin hydroxyalkyl derivative. The invention also relates to novel lyophilized or spray-dried erythropoietin compositions comprising a .beta.- or .gamma.-cyclodextrin hydroxyalkyl derivative, to processes for preparing such aqueous, lyophilized or spray-dried compositions and to a method for simultaneously stabilizing erythropoietin in an aqueous solution and preventing it from being adsorbed to surfaces.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.