Partial esters of (Di) chloromethanediphosphonic acid useful for treating disorders relating to the metabolism of calcium
US5376649A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 3, 1992 |
| Grant date | Dec 27, 1994 |
| Priority date | — |
| Expiry date | Feb 3, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/4081
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel pharmaceutically active bisphosphonic acid derivatives of formula (I), in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently are C.sub.1 -C.sub.22 -alkyl, C.sub.2 -C.sub.22 -alkenyl, C.sub.2 -C.sub.22 -alkynyl, C.sub.3 -C.sub.10 -cycloalkyl, C.sub.3 -C.sub.10 -cycloalkenyl, aryl, aralkyl, silyl and hydrogen, and R.sup.4 is different from hydrogen, Q.sup.1 is hydrogen, fluorine, chlorine, bromine or iodine, and Q.sup.2 is chlorine, bromine or iodine, including the stereoisomers, such as the geometrical isomers and optically active isomers, of the compounds, as well as the pharmaceutically acceptable salts of the compounds. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.