Process for producing 6.beta.,14.alpha.-dihydroxy-4-androstene-3, 17-dione amid 14.alpha.-hydroxy-4-androstene-3,6,17-trione from 4-androstene-3, 17-dione using myrothecium sp. ferm bp-4432
US5378611A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 19, 1993 |
| Grant date | Jan 3, 1995 |
| Priority date | — |
| Expiry date | Nov 19, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/911
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides a novel process for the production of 6.beta.,14.alpha.-dihydroxy-4-androstene-3,17-dione which comprises culturing a microorganism belonging to the genus Myrothecium and capable of hydrolyzing 4-androstene-3,17-dione to produce 6.beta.,14.alpha.-dihydroxy-4-androstene-3,17-dione in a medium supplemented with 4-androstene-3,17-dione, and isolating 6.beta.,14.alpha.-dihydroxy-4-androstene-3,17-dione from the cultured medium. According to the process of the present invention, 6.beta.,14.alpha.-dihydroxy-4-androstene-3,17-dione and 14.alpha.-hydroxy-4-androstene-3,6,17-trione can be produced with a high yield in a simple manner.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.