Process for preparing (2S,3R)-3-alkyl-phenylglycidic acid esters using lipase
US5378627A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 10, 1992 |
| Grant date | Jan 3, 1995 |
| Priority date | — |
| Expiry date | Aug 10, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/939
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for preparing optically active 3-phenylglycidic acid esters comprising reacting a racemic trans-3-phenylglycidic acid with an alkanol in the presence of a hydrolase to esterify preferentially either (2S, 3R) isomer or (2R, 3S) isomer of said racemic compound and isolating and collecting the resulting optically active 3-phenylglycidic acid ester from the reaction mixture, whereby the optically active ester can be produced in a single step and in a highly pure form. The optically active 3-phenylglycidic acid esters are useful for the preparation of 1,5-benzothiazepine derivatives having pharmacological activities such as platelet aggregation inhibitory activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.