Immobilization of biologically active substances with a polyphosphazene carrier
US5380658A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 16, 1993 |
| Grant date | Jan 10, 1995 |
| Priority date | — |
| Expiry date | Sep 16, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/816
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A phosphazene polymer carrier is prepared that has functional groups capable of binding a biologically active substance such as an enzyme or antibody and groups which are non-reactive and hydrophilic. A bifunctional aldehyde is reacted with primary amino groups of a shaped phosphazene polymer to form side chains having aldehyde groups, an amino group-containing compound is reacted with a portion of the aldehyde groups to produce the groups that are non-reactive and hydrophilic, and aldehyde groups not reacted are capable of binding a biologically active substance. The phosphazene polymer may be crosslinked prior to reacting with the bifunctional aldehyde. In another embodiment, a protecting agent is reacted with a portion of the aldehyde groups to block the aldehyde groups, imino bonds are reduced, a compound having an amino group is reacted with aldehyde groups not blocked to form the groups which are non-reactive and hydrophilic, and the protecting agent is removed to provide aldehyde groups capable of binding a biologically active substance. The non-reactive and hydrophilic groups may also be formed by reacting primary amino groups with formaldehyde or by diazotizing primary ami…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.