Truncated human serum albumin polypeptides as plasma expanding agents
US5380712A · kind A · utility
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Key dates
| Filing date | Feb 14, 1992 |
| Grant date | Jan 10, 1995 |
| Priority date | — |
| Expiry date | Feb 14, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Polypeptides corresponding to mature human serum albumin residues 1 to n, where n is between 369 and 419 inclusive, are useful as substitutes for albumin in the treatment of burns and shock in humans, the clearance of undesirable compounds, (such as bilirubin) from human blood, in laboratory growth media and in HSA assays. The polypeptides may be produced by recombinant DNA techniques, especially in yeast.
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