Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents
US5380721A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 31, 1994 |
| Grant date | Jan 10, 1995 |
| Priority date | — |
| Expiry date | May 31, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Aryl-fused- and hetaryl-fused-2,4-diazepines of formula XXXVI, benzodiazocines of formula XXX, benzodiazepines of formula II ##STR1## .delta.-aminoamides of formula III and aryldimethanamines of formula XXXVII ##STR2## wherein A is an aryl or hetaryl ring; PA0 R.sup.1 is hydrogen, alkyl, aryl or hetaryl; PA0 R.sup.2 is hydrogen, alkyl, substituted alkyl, or aryl; PA0 R.sup.3 is alkyl, aryl, aralkyl or heteroatom substituted alkyl or aralkyl; PA0 R.sup.4 is hydrogen or alkyl; PA0 R.sup.5 is hydrogen, alkyl, aryl or hetaryl; PA0 R.sup.6 is hydrogen, alkyl, alkoxy, halogen or a fused benzene ring; PA0 R.sup.9 is hydrogen, alkyl, or substituted alkyl; and PA0 R.sup.10 is hydrogen, alkyl, or substituted alkyl. The invention further relates to processes for the preparation of, pharmaceutical compositions containing, and methods of treating cardiac arrhythmia with the compounds of formulas XXXVI, XXX, II, III, and XXXVII.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.