2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents

US5380738A · kind A · utility

Assignee

• Monsanto Company · US

Inventors

• Bryan Hurst Norman · Indianapolis, US
• Len F. Lee · Holden, US
• Jaime Masferrer · Ballwin, US
• John J. Talley · Chesterfield, US

Key dates

• Filing date: May 21, 1993
• Grant date: Jan 10, 1995
• Expiry date: May 21, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D263/32
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

2-Substituted-4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazoles or 2-substituted-5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)oxazoles and derivatives thereof are found to posses significant antiinflammatory activity, especially useful for the treatment of arthritis without deleterious side effects.