Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
US5380747A · kind A · utility
63Cited by
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12Claims
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Key dates
| Filing date | Oct 30, 1992 |
| Grant date | Jan 10, 1995 |
| Priority date | — |
| Expiry date | Oct 30, 2012 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/323
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.