S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof

US5380758A · kind A · utility

Assignee

• The Brigham and Women's Hospital, Inc. · US

Inventors

• Jonathan S. Stamler · Chapel Hill, US
• Joseph Loscalzo · Dedham, US
• Adam Slivka · Randolph, US
• Daniel Simon · Newton, US
• Robert Brown · Carmel, US
• Jeffrey M. Drazen · Winchester, US

Key dates

• Filing date: Sep 14, 1992
• Grant date: Jan 10, 1995
• Expiry date: Sep 14, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

S-nitrosothiols exert a potent relaxant effect, mediated both by guanylate cyclase, and a cGMP-independent mechanism, upon non-vascular smooth muscle. Such types of smooth muscle include airway, gastrointestinal, bladder, uterine and corpus cavernosal. Thus, S-nitrosothiols may be used for the treatment or prevention of disorders associated with relaxation of smooth muscle, such as airway obstruction, and other respiratory disorders, bladder dysfunction, premature labor and impotence. Additionally, S-nitrosothiols may be used to alleviate smooth muscle contraction and spasm, and thus facilitate procedures involving diagnostic instrumentation, such as endoscopy, bronchoscopy, laparoscopy and cystoscopy. S-nitrosothiols also increase the binding affinity between hemoglobin and oxygen, and therefore, may be used to improve hemoglobin-oxygen binding, and oxygen transport to bodily tissues.