Method of making 3-methoxy-2,4,5-trifluorobenzoic acid
US5380926A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 28, 1994 |
| Grant date | Jan 10, 1995 |
| Priority date | — |
| Expiry date | Mar 28, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C51/38
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a method of making 3-methoxy-2,4,5-trifluorobenzoic acid. A tetrafluorophthalimide is reacted with an alkali metal hydroxide to produce a mixture of alkali metal salts of 4-hydroxy-3,5,6-trifluoro-N-alkylphthalamic acid and 3-hydroxy-2,4,5-trifluoro-N-alkylbenzamide. Those products are reacted with a methylating agent to produce 4-methoxy-3,5,6-trifluoro-N-alkylphthalamic acid and 3-methoxy-2,4,5-trifluoro-N-alkylbenzamide. Those products are reacted with an acid to produce 4-methoxy-3,5,6-trifluorophthalic acid and 3-methoxy-2,4,5-trifluorobenzoic acid. Finally, the 4-methoxy-3,5,6-trifluorophthalic acid is reacted with a decarboxylating agent to produce additional 3-methoxy-2,4,5-trifluorobenzoic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.