3,3-diphenylpropylamines and pharmaceutical compositions thereof

US5382600A · kind A · utility

Assignee

• Pharmacia Corporation · SE

Inventors

• Nils Ake Jonsson · Staffanstorp, SE
• Bengt Sparf
• Lembit Mikiver
• Pinchas Moses · Boo, SE
• Lisbet Nilvebrant · Bromma, SE
• Gunilla Glas · Sollentuna, SE

Key dates

• Filing date: Dec 19, 1991
• Grant date: Jan 17, 1995
• Expiry date: Dec 19, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/74
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

##STR1## Novel 3,3-diphenylpropylamines of formula (I) wherein R.sup.1 signifies hydrogen or methyl, R.sup.2, R.sup.3 and R.sup.4 independently signify hydrogen, methyl, methoxy, hydroxy, carbamoyl, sulphanoyl or halogen, and X represents a tertiary amino group -NR.sup.5, R.sup.6, wherein R.sup.5 and R.sup.6 signify non-aromatic hydrocarbyl groups, which may be the same or different and which together contain at least three carbon atoms, and which may form a ring together with the amine nitrogen, their salts with physiologically acceptable acids and, when the compounds can be in the form of optical isomers, the racemic mixture and the individual enantiomers, their use as drugs, especially as anticholinergic agents, their use for preparing an anticholinergic drug, pharmaceutical compositions containing the novel amines, and methods for preparing the same.