Platelet activating factor antagonists

US5382670A · kind A · utility

Assignee

• Abbott Laboratories · US

Inventors

• James B. Summers · Libertyville, US
• George S. Sheppard · Wilmette, US
• James G. Phillips · Bay Village, US
• Daisy Pireh · Lake Forest, US
• Douglas H. Steinman · Morton Grove, US
• Paul D. May · Richland, US
• Denise E. Guinn · Grayslake, US
• H. Robin Heyman · Chicago, US
• George M. Carrera, Jr. · Des Plaines, US
• Steven K. Davidsen · Libertyville, US

Key dates

• Filing date: Jul 7, 1993
• Grant date: Jan 17, 1995
• Expiry date: Jul 7, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.