Process for the preparation of 2-chloro-5-alkylaminomethyl-pyridines
US5382671A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Feb 9, 1993 |
| Grant date | Jan 17, 1995 |
| Priority date | — |
| Expiry date | Feb 9, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/61
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a new process for the preparation of 2-chloro-5-alkylaminomethyl-pyridines of the formula (I) ##STR1## in which R represents alkyl. In this process, 2-chloro-5-aminomethyl-pyridine is reacted with formic acid at temperatures between 20.degree. C. and 200.degree. C., if appropriate in the presence of a diluent, the 2-chloro-5-formylaminomethyl-pyridine which has been formed in this process is reacted without intermediate isolation (in situ) with alkylating agents at temperatures between 0.degree. C. and 100.degree. C., if appropriate in the presence of an acid acceptor, if appropriate in the presence of a diluent, and, finally, the 2-chloro-5-(N-alkyl-N-formyl-aminomethyl)-pyridines thus formed of the general formula (V) ##STR2## in which R has the abovementioned meaning, are reacted with aqueous alkali metal hydroxide solution at temperatures between 20.degree. C. and reflux temperature, if appropriate after volatile components have been distilled off. The compounds (I) are, for example, intermediates for the preparation of insecticidally active substances.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.