Process for preparing florfenicol, its analogs and oxazoline intermediates thereto
US5382673A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 22, 1993 |
| Grant date | Jan 17, 1995 |
| Priority date | — |
| Expiry date | Apr 22, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C317/32
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing a compound of formula (IV): ##STR1## comprising a) contacting an oxazoline compound of formula (I): ##STR2## wherein Z is as defined hereinbefore, with a reagent capable of causing an equilibrium between oxazoline compound (I) and an oxazoline compound of formula (II) described herein, and the reagent drives the equilibrium toward oxazoline compound (II) by preferential precipitation of oxazoline compound (II); PA0 b) contacting compound (II) with a fluorinating agent to give a fluorinated oxazoline compound of formula (III) described herein; and PA0 c) hydrolyzing the compound of formula (III) to formula (IV). In an alternative embodiment, the process is directed toward a process for preparing oxazoline (II) in a single step.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.