Pharmaceutically active 1,2,4-triamino-benzene derivatives, processes for their preparation and pharmaceutical compositions containing them

US5384330A · kind A · utility

Assignee

• Asta Medica Aktiengesellschaft · DE

Inventors

• Hans-Reinhold Dieter · Darmstadt, DE
• Jurgen Engel · Alzenau, DE
• Bernhard Kutscher · Maintal, DE
• Emanuel Polymeropoulos · Frankfurt, DE
• Stefan Szelenyi · Arnstorf, DE
• Bernd Nickel · Mühltal, DE

Key dates

• Filing date: Jan 8, 1993
• Grant date: Jan 24, 1995
• Expiry date: Jan 8, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C275/40
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmacologically active 1,2,4-triaminobenzene derivatives of the General Formula I: ##STR1## where the symbols R1' R2' R3' R4' R5' Ar and Alk have the following meanings: where the symbols R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, Ar and Alk have the following meanings: PA0 R.sub.1 : hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkanoyl or the radical Ar; PA0 R.sub.2 : hydrogen or C.sub.1 -C.sub.6 -alkyl; PA0 R.sub.3 : C.sub.1 -C.sub.6 -alkoxy, NH.sub.2, C.sub.1 -C.sub.6 -alkylamino, C.sub.1 -C.sub.6 -dialkylamino, amino substituted by the radical Ar, C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -alkynyl, the radical Ar or the radical ArO--; PA0 R.sub.4 : hydrogen, C.sub.1 -C.sub.6 -alkyl or the radical Ar; PA0 R.sub.5 : hydrogen or C.sub.1 -C.sub.6 -alkyl or the radical Ar; PA0 Alk: a straight or branched alkylene group containing 1-9 carbon atoms, which can also be substituted by the radical Ar.