Compositions of iodobenzoic acid derivatives and cellulose derivatives for visualization of the gastrointestinal tract
US5385720A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 23, 1994 |
| Grant date | Jan 31, 1995 |
| Priority date | — |
| Expiry date | Mar 23, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K49/0433
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an x-ray producing agent of the formula or a pharmaceutically acceptable salt thereof ##STR1## wherein Z is H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; PA1 R is C.sub.1 -C.sub.25 alkyl, cycloalkyl, or halo-lower-alkyl, each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy; PA1 (CR.sub.1 R.sub.2).sub.p -- (CR.sub.3 =CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p -- C.dbd.C--Q; PA1 R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently lower-alkyl, optionally substituted with halo; PA1 x is 1--3 PA1 y is 1--4; PA1 n is 1--5; PA1 m is 1--15; PA1 p is 1--10; and PA1 Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl in a pharmaceutically acceptable carrier comprising a cellulose derivative.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.