Compositions of alkylbenzenes and cellulose derivatives for visualization of the gastrointestinal tract

US5385721A · kind A · utility

Assignee

• Sterling Winthrop Inc. · US

Inventors

• Edward J. Baker · Rothbury, GB
• Kurt A. Josef · Wayne, US
• Edward R. Bacon · East Greenbush, US
• Kimberly G. Estep · Pottstown, US
• Carl R. Illig · Phoenixville, US
• Brent Douty · Coatesville, US
• John L. Toner · Libertyville, US
• Robert W. Lee · Gilbertsville, US

Key dates

• Filing date: Mar 22, 1994
• Grant date: Jan 31, 1995
• Expiry date: Mar 22, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C69/65
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an x-ray producing agent of the formula or a pharmaceutically acceptable salt thereof ##STR1## wherein R is methyl, ethyl, n-propyl, C.sub.4 -C.sub.25 alkyl, cycloalkyl, unsaturated allyl or halo-lower-alkyl, each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl; (CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q; PA0 R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently H, lower-alkyl, optionally substituted with halo; PA0 n is 2-5; PA0 m is 2-5; PA0 p is 1-10; and PA0 Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl; in a pharmaceutically acceptable carrier comprising a cellulose derivative.