Bradykinin antagonist peptides
US5385889A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 16, 1993 |
| Grant date | Jan 31, 1995 |
| Priority date | — |
| Expiry date | Dec 16, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with a D-configuration hydroxyproline ether or thioether converts bradykinin agonists into bradykinin antagonists. The invention further includes the intermediate compounds and additional modifications at other positions within the novel 7-position modified bradykinin antagonists which increase enzyme resistance, antagonist potency, and/or specificity of the new bradykinin antagonists. The analogs produced are useful in treating conditions and diseases of a mammal and human in which an excess of bradykinin or related kinins are produced or injected such as by insect bites.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.