Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
US5385912A · kind A · utility
50Cited by
6References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 13, 1992 |
| Grant date | Jan 31, 1995 |
| Priority date | — |
| Expiry date | Oct 13, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to polycyclic compounds containing two mono- and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention. The compounds of this invention are described by the formula ##STR1## where Ar I is phenylene or naphthylene, Ar II is phenyl or naphthyl and A is 1-azabicyclo[2.2.2]octan-3-yl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.