Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation

US5385915A · kind A · utility

Assignee

• The Rockefeller University · US

Inventors

• Joseph D. Buxbaum · New York, US
• Samuel E. Gandy · New York, US
• Paul Greengard · New York, US

Key dates

• Filing date: Jun 7, 1993
• Grant date: Jan 31, 1995
• Expiry date: Jun 7, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/47
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of regulating phosphorylation of proteins involved in controlling processing or function of key proteins found in intracellular neurofibrillary tangles and extracellular amyloid plaques associated with Alzheimer disease comprising introducing an effective amount of a kinase modulator or phosphatase modulator, the modulator capable of increasing or decreasing the rate of proteolytic processing, or modulating the function, of said key proteins.