Method for enhancing delivery of chemotherapy employing high-frequency force fields
US5386837A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Feb 1, 1993 |
| Grant date | Feb 7, 1995 |
| Priority date | — |
| Expiry date | Feb 1, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B18/00
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Pulse shocks of high-frequency wave energy (e.g. RF, microwave, high-energy infra-red or laser electromagnetic wave energy or ultrasonic acoustic wave energy), rather than DC electric pulses, are employed to non-invasively produce force fields of an intensity sufficient to create transient pores in the plasma membranes of targeted cells, such as tumor cells or other diseased cells, through which either locally or systemically applied drug or chemotherapeutic agents can easily enter and be taken up by the targeted cells, even for (1) the cells of a deep-seated tumor, (2) non-localized metastasized tumor cells within a patient's body, or (3) cells (e.g., blood cells) temporarily removed to outside of a patient's body.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.