System for controlled release of antiarrhythmic agents
US5387419A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 26, 1993 |
| Grant date | Feb 7, 1995 |
| Priority date | — |
| Expiry date | Mar 26, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/7007
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A system for controlled release, site-specific delivery of therapeutic agents, particularly myocardial agents such as antiarrhythmic agents, comprises a biocompatible polymeric matrix with an incorporated therapeutic agent for direct placement at the epicardium. Advantageously, the dosage form can be fabricated in such a manner as to tailor the release characteristics as required by the nature of the physical condition desired to be treated. In a specific illustrative embodiment, lidocaine, an antiarrhythmic depressant, is incorporated in polyurethane by a unique method which permits drug-loading of the polymeric matrix from about 5% up to 40% by weight, with about 25% to 30% in a preferred embodiment. A novel FeCl.sub.3 catalyst causes the polyurethane to polymerize despite the presence of drug in the polymeric matrix mixture.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.